海珠湾隧道是打通广州中心城区与南站枢纽快速连通的重要组成部分，具有接线路网复杂、超大直径、地质条件复杂及沿线结构物密集等难点，隧道总体设计难度大。首先，详细阐述隧道建设的意义，综合考虑总体规划、农田占用、征地拆迁和环境效应等因素，探索最优的平面线位，通过分析提出合理的技术指标；同时基于隧道建设条件与特点，制定沿线敏感结构物力学扰动评价指标和标准，开展隧道工法比选分析。然后，对推荐的盾构法进行横断面方案比选，并借助数值法评价不同断面方案诱发的既有结构力学响应，以支撑方案优选设计。最后，明确实施控制条件，进行推荐方案的平面、纵断面设计研究，并分析隧道建设关键技术； 针对海珠湾隧道建设特点，通过多因素综合比选，形成合理的工程总体设计方案。

Haizhu Bay tunnel is a crucial component for establishing a fast connection between the central urban area and the south station hub in Guangzhou. The general design is challenging due to its complex connection network, superlarge diameter, complex geological conditions, and dense structures along the line. The significance of the tunnel construction is elaborated, and the optimal plane line is explored taking into account overall plan, farmland occupation, land acquisition and demolition as well as environmental effects, and then the reasonable technical indicators are proposed. Meanwhile, the mechanical disturbance evaluation indicators and standards for sensitive structures along the line are formulated based on the conditions and characteristics of tunnel construction, and the tunnel construction methods are analyzed and selected. The crosssection schemes for the recommended shield method are compared and selected, and mechanical response of existing structures induced by different section schemes are evaluated by using numerical method. Clarifying the control conditions, the design of plane and longitudinal sections for the recommended scheme as well as the key technologies are analyzed. In view of the construction characteristics of Haizhu Bay tunnel, a reasonable general design scheme has been formed through a comprehensive analysis of multiple factors.