为研究地基的不均匀性对沉管隧道变形及损伤的影响，以广州车陂路—新滘东路沉管隧道工程为背景，采用荷载-结构法建立考虑管节损伤的三维有限元计算模型，研究不同横向地基刚度条件下沉管隧道的沉降和管节损伤。结果表明： 1）在横向地基刚度为均匀分布的情况下，沉管隧道顶板的最大变形为11.6 mm。2）横向地基刚度不均匀会导致相邻管节接头处的差异沉降；横向地基刚度分布模式会影响沿隧道轴线方向的沉降，由横向地基刚度的不同所引起管节间的最大差异沉降出现在E2-2和E3之间的接头位置，分段式分布模式时接头的差异沉降大于线性分布模式时的差异沉降；横向地基刚度的连续性和均匀性对沉管混凝土的损伤具有重要影响。3）混凝土的损伤主要分布在沉管的顶板和底板在中墙位置的区域及两室底板位置，且两室底板混凝土的损伤受横向地基刚度变化较为敏感，需根据实际情况对易损伤区域采取适当的加强措施，以确保其安全。

To explore the influence of differential lateral foundation stiffness on the immersed tunnel, a case study is conducted on the immersed tunnel project between Chebei road station and Xinjiao east road station in Guangzhou. A threedimensional finite element model incorporating damage is established using load-structure method to analyze the settlement and segment damage of immersed tunnel under different lateral foundation stiffness. The results show that the maximum deformation is 11.6 mm in case of uniform distributed lateral foundation stiffness. It is revealed that: (1) The differential lateral foundation stiffness will induce differential settlement in adjacent segment joints. (2) The distribution pattern of lateral foundation stiffness will affect the settlement along the tunnel axis, the maximum differential settlement caused by the differential lateral foundation stiffness occurs at the joint between E22 and E3, and the differential settlement of the joint under segmented distribution pattern is greater than that under linear distribution pattern. (3) The continuity and uniformity of the lateral foundation stiffness can affect damage of concrete remarkably. The damage of concrete is mainly distributed in the area of the roof and bottom plate of the immersed tube near the middle wall, as well as the twochamber floor. The latter is more sensitive to the change of the lateral foundation stiffness. Thus, some measures should be adopted to ensure its safety.