Due to the extremely complex factors, it is very difficult to predict the settlement and deformation of Metro tunnels close to largescale deep foundation pits. Therefore, it is impossible to determine the safety conditions of the Metro tunnels and it is also impossible to provide guidance for the construction of the foundation pits. Ant colony algorithm model is established on basis of TSP basic ant algorithm model, actual settlement and deformation of Metro tunnels, determination of the path of the ant colony algorithm model, establishment of information function and heuristic function, and determination of pheromone updating mechanism and antsearching mechanism, so as to predict the settlement of Metro tunnels. The effect of the ant colony algorithm model is validated in engineering cases. The ant colony algorithm model provides a new way for the prediction of the settlement of operating Metro tunnels, especially those close to largescale deep foundation pits.