According to the original design, separate launching of a large diameter shield machine is to be made at Puzhulu Station on Line 3 of Nanjing Metro In the later stage, however, it is decided that integral shield machine launching is to be implemented to replace the original separate launching Therefore, the structure of the Metro station should be treated In the paper, the influence of the integral launching of the large diameter shield machine on the Metro station is analyzed, the key points of the treatment of the structure of the Metro station are summarized, solution of underpinning by concrete beams and columns is proposed, and calculation is made for the underpinning system by means of 2D and 3D models based on SAP2000 finite element software Conclusion is drawn that the underpinning system adopted for the Metro station is feasible and rational