Due to the large crosssections, great construction difficulties, serious risks and long construction periods, the mined ventilation passages of Metro stations are critical and difficult points in the construction of Metro stations. In the paper, 4 layout modes of ventilation passages of integrated looped environment control system, including installing separate ventilation passage, combining the ventilation passage with the running tunnel, lengthening the main station structure and combining the ventilation passage with the main station structure, and installing another span for the main station structure and combining the ventilation passage with the main station structure, are studied, and the characteristics and application conditions of the 4 mentioned layout modes are analyzed. Case study in made on Liaogongzhuang Station on West Extension Project of Line 6 of Beijing Metro, and the architectural functions, structural features, engineering, investment and cost of the station under different ventilation passage layout modes are compared and analyzed. Conclusion is drawn that the 2 solutions of combining the ventilation passage with the main station structure have more advantages. The paper can provide reference for the design of the ventilation passages of other Metro stations in the future.