The running tunnel from Taipingjiao Park Station to Yan’an Road Station of No. 3 Line of Qingdao Metro crosses underneath a plastic surgery hospital. In the paper, the blasting parameters under the condition of largediameter empty hole parallel cut, including empty hole diameter, blasting hole number, the space between the firstblasting hole and the empty hole, the detonating delay time and the position of the empty hole, are discussed on basis of theoretical analysis and field test, so as to minimize the influence of the blasting on the existing surface buildings. The results show that the empty hole diameter should be 120~150 mm, 4 blasting holes should be drilled around the empty hole, the distance between the firstblasting hole and the empty hole should be 200~350 mm, and the detonating delay time should be longer than 40 ms.