Tunneling by slurry shield inevitably produces a large amount of waste slurry and waste mucks, and how to deal with the waste slurry and waste mucks in an economical and environmentfriendly manner is a big challenge for the project. In the construction of Weisanlu Yangtze River Crossing Tunnel in Nanjing, the difficulty in the slurry treatment is analyzed, rational slurry treatment plant is established, proper slurry treatment equipment is selected, and specific slurry mixing proportions and slurry separation equipment operation modes are used for different geological sections, which results in the efficient and highquality supply of slurry and the successful implementation of the project. Furthermore, the clay mucks and the waste clay slurry are used to prepare fresh slurry for the shield boring, the fine sand mucks are used to prepare the backfilling grout and the gravel cobble mucks are used as aggregate for concrete mixing. In the end, great economic and environmental benefits are achieved. The practice provides a new way for the slurry treatment and muck recycling use for other projects in the future.