The pipe abrasion of slurry circulation system will lead to an abnormal stop of shield tunneling and construction risk. Therefore, the influencing factors, including slurry material, slurry transportation speed, slurry density and solid particle size, of slurry pipe abrasion of slurry shield used in Line No. 10 of Nanjing Metro are studied. And then some effective countermeasures for reducing the pipe abrasion of slurry circulation system are proposed by means of comparison between actual testing results and study results,so as to provide reference for rational design of slurry circulation system by improving the construction efficiency and safety.