The wear and vibration of slurry pipe of slurry shield boring in largediameter cobble stratum of a bid section of Lanzhou Metro are studied; and then the causes of wear and vibration of slurry pipe are analyzed. A series of improvements, i.e. eccentric thickening of slurry pipes, entirety casting of integrated surface, increasing wear rings in the scour surface, adding lining on pipe inner wall with high chromium molybdenum antiwear alloy steel and installing shock absorber on the connection of pipelines, are carried out. The wear resistance property of the slurry pipe has been obviously improved; and its vibration has been reduced.