The Yangtze Rivercrossing highwayMetro integrated tunnel on Sanyang Road in Wuhan has many difficulties, i.e. high environmental protection, large length, limit space and hard ventilation system design. The ventilation system of the tunnel directly affects the construction investment, operation cost, traffic safety and fire rescue. For environmental protection of tunnel portal, the airflow, initial investment and operation cost of different ventilation schemes are studied; and the ventilation scheme of airblow and airexhaust through vertical shaft is adopted; for high fire rescue requirement, the attention should be paid to smoke exhausting of highway tunnel and the sectional longitudinal smoke exhausting method is adopted for Metro tunnel. Finally, a typical fire case is simulated and calculated.