The largescale Metro interchange station is the key to the design of Metro station. The Xi’an North Railway Station is the interchange station between Airport Line and Line No. 4 of Xi’an Metro. The environmental control of the interchange station is difficult. As a result, the control factors of the interchange station surrounding environment are analyzed; and the influence of ventilation shaft on North Xi’an North Railway Station Square, that of crossrail ventilation gallery on the interchange station scale and smoke control of escalator between hall and platform are discussed. Finally, the airconditioning system is decided and the application results are good. The results can provide reference for environmental control design of interchange station.