In this paper, a number of practices of smoke exhaust scheme for entrance and exit of metro station are introduced; the smoke exhaust scheme for entrance and exit of metro station is divided into 5 kinds; advantages and disadvantages of the schemes, i.e. the smoke exhaust fan set at station system room, smoke exhaust machine room set beside underground passageway, smoke exhaust machine room set on ground connected with entrance and exit, smoke exhaust machine room set on top of entrance and exit, and smoke exhaust fan set on top of entrance and exit, are analyzed in terms of air organization, environment influence and smoke exhaust effect, etc. The smoke prevention schemes for multistage lifting entrance and exit with height larger than 10 m are designed. Optimal smoke exhause schemes are obtained for several situations. The results can provide reference for smoke exhaust scheme design for entrance and exit of metro station.