To optimize the construction of the prefabricated station effectively and improve the accuracy of equipment lifting, the key construction technologies of the prefabricated station are studied with a case study of the Shizhongyiyuan station of the second phase of Shenzhen metro line 13. The section design of assembled components, prefabrication quality control of components, transportation equipment selection, and transportation process control, onsite construction site layout requirements, design and selection of highprecision gantry crane, design optimization of lifting process, selection of foundation reinforcement treatment scheme during construction, precision control of fine flat belt construction, accurate lifting and positioning of large volume components, tension process optimization and quality control, grouting process optimization and process quality control, sidewall fertilizer tank backfilling, and waterproof quality control are summarized and optimized, and core technical data such as technical parameters, lifting technical parameters, and tension parameters of highprecision gantry crane are obtained. The problems such as uneven settlement, untightness of fertilizer tank backfill, and leakage are summarized and analyzed, and the solutions are proposed.