Due to the water/sand leakage encountered at the bottom of No. 2 vertical shaft of Shenmu water transfer project, the vertical shaft is flooded and the construction has to be suspended. In order to solve this problem, grouting method is selected after numerous researches. Various grouting materials are trialed, the grouting techniques are optimized and the difficulty of grouting in 84mdeep vertical shaft under 0.6MPa hydraulic pressure is overcome. The successful sealing of the water/sand leakage improves the construction conditions of the vertical shaft and ensures the successful execution of the following works.