Sirenbanao Tunnel is about 4.8km long from Macheng to Wuhan in the ShanghaiChengdu highway. The ventilation system in this tunnel is the difficult key point in the design. The main ventilation schemes are compared in this paper. Based on the appropriate location of the inclined shaft and the vertical shaft, the vertical full jet current ventilation and longitudinal blowin and exhaust ventilation are analyzed to ensure safety and economy during the operation of the tunnel.